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New article published in Cancers
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Catégories
New article published in Marine Drugs
We’ll talk about the dialogue between the vascular microenvironment and the tumor. Come join us!
Intercellular Communication Club proposes to meet on Friday at 11am room 635, IRS-UN.
Isabelle Corre (Team 6), Sara Rosinska (Team 6) and Lucas Treps (Team 1) will lead the session. You are all welcome!
We look forward to hearing from you,
We reviewed the different approaches developed to selectively inhibit IL-15 action in order to reduce its harmful effect in diseases. You are welcome to read it, it’s in free access!
Note: One of our illustration is on the cover!!
Agnès Quéméner realized the figures and participated to the discussion of the article.
We’ll talk about the crosstalk between cancer cells and immune cells in the tumor microenvionement with Nicolas Boisgerault, team 1. Come join us!
Intercellular Communication Club proposes to meet on Friday Sept. 16th. at 11am room 635, IRS-UN.
We look forward to hearing from you,
We’ll talk about exosomes and flow cytometry. Come join us!
Intercellular Communication Club proposes to meet on Friday at 11am room 635, IRS-UN.
We will discuss the latest advances and future possibilities of microvesicles analysis by flow cytometry. Delphine Fradin (Team 1), Laetitia Guevel (Team 6) and Erwan Mortier (Team 12/ Mocka) will lead the session. You are all welcome!
We look forward to hearing from you,
When: Wednesday, June 15th, 2022, 14 p.m.
Where: Faculty of Science, Amphi G, Bld 28.
Title: Design, Synthesis and Evaluation of Small Molecule Inhibitors of the Interleukin (IL)-15 System.
| Abstract: Interleukin (IL)-15, is a pleiotropic cytokine structurally close to IL-2, both sharing the IL-2Rβ and γc receptor subunits. IL-15 plays important roles in innate and adaptative immunity, supporting the activation and proliferation of NK, NK-T, and CD8+ T cells. In case of dysregulation, high levels of IL-15 have been detected, leading to abnormal immune responses and autoimmune or inflammatory diseases such as polyarthritis rheumatoid or psoriasis. Hence, our goal is to synthesize small molecule inhibitors that bind specifically to IL15 on the IL-2Rβ interface. Herein, we describe two new families of IL-15 inhibitors. | Taking advantage of our previous work, extending modifications were done on our first series called IBI. On a second time, we applied a similar docking-based virtual screening of compounds libraries on a refined pharmacophore-based on IL-15 specific residues identified on the binding site of IL-15 with IL- 2Rβ giving so our second family named IBIS. These series of compounds were evaluated for their capacity to inhibit the binding to IL-15 to its cognate receptor, as well as the down-stream signaling of IL-15-dependent cells and their proliferation |
The Mocka Lab just published a new article published in the Journal « Frontiers in Immunology »
Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation. Meghnem D., Maillasson M., Barbieux I., Morisseau S., Keita D., Jacques Y., Quéméner A., and Mortier E. Front. Immunol. 13:886213.